Materials for Biomedical Engineering

Aim

After completion of the course the student should be able to:

• describe different types of materials used for biomedical applications as well as their properties making them useful as biomaterials, from nano- to macro level
• give examples of commonly used materials for biomedical applications
• describe and explain how cells and tissues are affected by the introduction of a foreign material
• describe in which way nano probes may be used in biomedical applications
• explain and be able to apply some methods for characterization of biomaterials and their interaction with cells and tissue.
• be aware of and able to describe some commonly used strategies for conjugation of biomolecules to materials and the involved chemical interactions. In addition, to have knowledge about some selected biochemical concepts often utilized in biomaterial and biosensor science. Course content Materials commonly used for medical applications (biomaterials), demands on a material intended for biomedical use, surface modification of biomaterials and methods for studying biomaterials and their interaction with its surroundings. Biocompatibility, cell/tissue biomaterial interaction, protein adsorption, coagulation and complement activation, wound healing, inflammation, tissue engineering. Nano probes as tools in medicine and imaging. Drug delivery, biomaterial induced pharmacological modulation of tissue responses. Selected basic chemistry with focus on conjugation chemistry, biochemistry and interaction chemistry. This part of the course is preparatory for the rest of the course as well as for ”Introduction to Biosensors”. Teaching and working methods Lectures and laborations. Preparation of a poster Examination KTR1Written test2 creditsU, GLAB2Laboratory work2 creditsU, GTEN2Written examination4 creditsU, 3, 4, 5Grades for examination modules are decided in accordance with the assessment criteria presented at the start of the course. Grades Four-grade scale, LiU, U, 3, 4, 5 Other information About teaching and examination languageThe teaching language is presented in the Overview tab for each course. The examination language relates to the teaching language as follows: If teaching language is “Swedish”, the course as a whole could be given in Swedish, or partly in English. Examination language is Swedish, but parts of the examination can be in English.If teaching language is “English”, the course as a whole is taught in English. Examination language is English.If teaching language is “Swedish/English”, the course as a whole will be taught in English if students without prior knowledge of the Swedish language participate. Examination language is Swedish or English depending on teaching language.OtherThe course is conducted in such a way that there are equal opportunities with regard to sex, transgender identity or expression, ethnicity, religion or other belief, disability, sexual orientation and age.The planning and implementation of a course should correspond to the course syllabus. The course evaluation should therefore be conducted with the course syllabus as a starting point. The course is campus-based at the location specified for the course, unless otherwise stated under “Teaching and working methods”. Please note, in a campus-based course occasional remote sessions could be included. Department Institutionen för fysik, kemi och biologi Course literature BooksWagner, William, (2020) Biomaterials science : an introduction to materials in medicine. Fourth edition. London, England : Academic Press, [2020] ISBN: 9780128161388

Content

Materials commonly used for medical applications (biomaterials), demands on a material intended for biomedical use, surface modification of biomaterials and methods for studying biomaterials and their interaction with its surroundings. Biocompatibility, cell/tissue biomaterial interaction, protein adsorption, coagulation and complement activation, wound healing, inflammation, tissue engineering. Nano probes as tools in medicine and imaging. Drug delivery, biomaterial induced pharmacological modulation of tissue responses.

Selected basic chemistry with focus on conjugation chemistry, biochemistry and interaction chemistry. This part of the course is preparatory for the rest of the course as well as for ”Introduction to Biosensors”.