Industrial Biotechnology

Aim

Fundamental understanding of industrial biotechnology with focus on products such as drugs, food, chemicals, renewable energy sources and instruments and process equipment. Understanding of metabolic and cell biological processes from engineering perspectives. After the course the student shall be able to: 1) Describe the fundamental biological and engineering principles for production of proteins, metabolites and cells and devices and apparatuses. 2) Understand the principles for engineering design of key unit operations and other functional operations such as bioreactor cultivation and chromatographic separation of bioproducts and analytical instruments. 3) Carry out engineering computations and simulations of bioprocesses based on physical, chemical and biological fundamentals using basic mathematical equations and models.

Content

The lectures cover fundamentals about industrial production using bioprocesses. This includes methods for cultivation in bioreactors and recovery of bioproducts using separation methods. Engineering modelling methods are used to calculate key process parameters. Content of lectures: Biochemistry and physiology of cell growth and metabolism. "The Cell Factory" concept. Bioreactor design for batch, fed-batch and chemostat. Purification and separation processes. Using dynamic models and differential equations based on balances and microbial kinetics. Design of unit operations for cultivation and bioseparation. Typical industrial bioprocesses are illuminated (e.g. production of antibiotics, biogas, industrial enzymes, therapeutic proteins, vaccines, mammalian cells, stem cells and environmental applications).