Molecular Physiology and Cell Signaling Mechanisms

Aim

The student will increase her/his understanding of the role of selected molecules on the function of the human body by focusing on the relationship between molecular structure and intracellular function.

After the completion of the course the student will be able

• To identify the fundamental intracellular signaling pathways in animal cells
• To understand how cells are activated by membrane and intracellular receptors
• To integrate cellular pathways to physiological regulatory mechanisms

At the same time, the student will improve her/his ability

• To seek, compile and critically evaluate primary research articles
• To accurately describe cellular and organ processes in a scientific manner

Content

The course is centered around different molecules or families of molecules that are relevant to the function of the human body and also its pathology, namely:

• Erythropoietin and nitric oxide involved in oxygen transport and vascular regulation
• Voltage gated potassium channels involved in neuronal and cardiac excitability and associated to long QT syndrome and sudden death
• Voltage gated calcium channels and calcium pumps (ryanodine receptor and sarcoplasmic reticulum calcium ATPase) involved in muscle contraction and relaxation and associated to malignant hyperthermia
• G-protein coupled receptors, with special emphasis on beta-adrenergic receptors and angiotensin receptors. Involved in cardiovascular regulation and fluid homeostasis
• Transient-receptor potential channels (TRP) involved in sensory transduction of temperature, pain and mechanical stimulus.