Biomedical Modeling and Simulation

Aim

The objective of the course is to introduce and apply general theories for modelling and simulation of systems relevant to biomedical engineering. This includes both physical and physiological models. After passing the course the student should be able to:

• describe general principles for modeling and simulating a system and apply these when designing mathematical models for several realistic systems.
• evaluate the applicability of principles for different models and simulation techniques on biomedical engineering problems related to diagnostic and therapeutic or physiological research
• implement and analyze computer-based modeling and simulation for studying research-relevant problems in biomedical engineering.

Content

Introduction to concepts of system modeling, model formalism and it's relationship to different simulation strategies. Application of general and specific methods to analyze and model systems. Implementation and simulation of models in a computing environment. Discrete-time and stochastic simulation methods. Evaluation of model applicability, accuracy and robustness. Research based projects and laboratory work. The laboratory activities comprise:

• Simulation of airflow in the lungs.
• 3D simulation with FEM technology of heat transfer in human tissue.
• Stochastic simulation of light transport in human tissue.
• Simulation of action potential generation across the cell membrane.